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Open Access Green as soon as Postprint is submitted to ZB.
Aerosol delivery during mechanical ventilation to the rat.
Exp. Lung Res. 30, 635-651 (2004)
The authors have adjusted a jet nebulizer to a mechanical ventilator (Servo Ventilator, Siemens) to deliver an aerosol to rats. They aimed to clarify whether a modified jet nebulizer generating particles with a mass median aerodynamic diameter of 2 µm would be effective and safe in intubated ventilated rats. Fluorescent microspheres (diameter: 1.0 µm) were aerosolized to verify qualitatively and quantitatively intrapulmonary deposition. Particle deposition fraction was 3.8% (1.3%) of the delivered dose (median [interquartile range]). There was no evidence for any adverse event as assessed from heart rate, mean arterial pressure, PaO2 and PaCO2 before, during, and after nebulization. No pulmonary tissue trauma was detected histologically.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
aerosol; animal experimentaion; nebulizers
ISSN (print) / ISBN
0190-2148
e-ISSN
1521-0499
Journal
Experimental Lung Research
Quellenangaben
Volume: 30,
Issue: 7,
Pages: 635-651
Publisher
Informa Healthcare
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Lung Biology (LHI)