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Reininger, C.B.* ; Lasser, R. ; Rumitz, M.* ; Böger, C.* ; Schweiberer, L.*

Computational analysis of platelet adhesion and aggregation under stagnation point flow conditions.

Comput. Biol. Med. 29, 1-18 (1999)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
The clinical relevance of platelet function assessment with stagnation point flow adhesio-aggregometry (SPAA) has been verified. Quantitative analysis of platelet adhesion and aggregation is possible by means of mathematical analysis of the dark-field, light intensity curves (growth curves) obtained during the SPAA experiment. We present a computational procedure for evaluating these curves, which was necessitated by, and is based on, actual clinical application. A qualitative growth curve classification, corresponding to a basic and distinct pattern of platelet deposition and characteristic of a regularly occurring clinical state is also presented.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Stagnation point flow adhesio-aggregometry (SPAA); Platelet adhesion; Platelet aggregation; Peripheral arterial disease (PAD); Morphology; Light intensity curve; Mathematical model; kpp; kpw
Language english
Publication Year 1999
HGF-reported in Year 0
ISSN (print) / ISBN 0010-4825
e-ISSN 1879-0534
Journal Computers in Biology and Medicine
Quellenangaben Volume: 29, Issue: 1, Pages: 1-18 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) Institute of Biomathematics and Biometry (IBB)
DOI 10.1016/S0010-4825(98)00039-0
Erfassungsdatum 1999-12-31
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