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Open Access Green as soon as Postprint is submitted to ZB.
Computational analysis of platelet adhesion and aggregation under stagnation point flow conditions.
Comput. Biol. Med. 29, 1-18 (1999)
The clinical relevance of platelet function assessment with stagnation point flow adhesio-aggregometry (SPAA) has been verified. Quantitative analysis of platelet adhesion and aggregation is possible by means of mathematical analysis of the dark-field, light intensity curves (growth curves) obtained during the SPAA experiment. We present a computational procedure for evaluating these curves, which was necessitated by, and is based on, actual clinical application. A qualitative growth curve classification, corresponding to a basic and distinct pattern of platelet deposition and characteristic of a regularly occurring clinical state is also presented.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Stagnation point flow adhesio-aggregometry (SPAA); Platelet adhesion; Platelet aggregation; Peripheral arterial disease (PAD); Morphology; Light intensity curve; Mathematical model; kpp; kpw
ISSN (print) / ISBN
0010-4825
e-ISSN
1879-0534
Quellenangaben
Volume: 29,
Issue: 1,
Pages: 1-18
Publisher
Elsevier
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Biomathematics and Biometry (IBB)