PuSH - Publication Server of Helmholtz Zentrum München: Nrf2 induces interleukin-6 (IL-6) expression via an antioxidant response element within the IL-6 promoter.

Information

Clues to quality of journals

Open Access Policy of Helmholtz Association 2016

CC Licencences

Publication Metrics

Navigation

Home

Deutsch

EVA: Electronic Publishing

New EVA Application

Research

Advanced Search

Browse by ...

... HMGU-Authors/Consortia

... Organizational Structure

... Journal

... Publication Type

... Research Data

... Arbeitsgruppen

... Publication Year

Publication overview

Statistics

Statistics (last 5 years)

OA Publications

Publish

Submit Publication

Import publication from...

...EVA

Report missing publication

Highlights

Support & Contact

Contact persons

Help

Data protection

Helmholtz Open Science

JANE Journal Estimator

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Wruck, C.J.* ; Streetz, K.* ; Pavic, G.* ; Götz, M.E.* ; Tohidnezhad, M.* ; Brandenburg, L.O.* ; Varoga, D.* ; Eickelberg, O. ; Herdegen, T.* ; Trautwein, C.* ; Cha, K.* ; Kan, Y.W.* ; Pufe, T.*

Nrf2 induces interleukin-6 (IL-6) expression via an antioxidant response element within the IL-6 promoter.

J. Biol. Chem. 286, 4493-4499 (2011)

Publ. Version/Full Text

DOI

PMC

	Open Access Gold

Abstract
Metrics
Extra information

IL-6 gene expression is controlled by a promoter-region containing multiple regulatory elements such as NF-kB, NF-IL6, CRE, GRE and TRE. In this study, we demonstrated that TRE, found within the IL-6 promoter, is embedded in a functional antioxidant response element (ARE) matching an entire ARE consensus sequence. Further, point mutations of the ARE consensus sequence in the IL-6 promoter construct selectively eliminate ARE but not TRE activity. Nrf2 is a redox-sensitive transcription factor which provides cytoprotection against electrophilic and oxidative stress and is the most potent activator of ARE-dependent transcription. Using Nrf2 knockout mice we demonstrate that Nrf2 is a potent activator of IL-6 gene transcription in vivo. Moreover, we show evidence that Nrf2 is the transcription factor that activates IL6 expression in a cholestatic hepatitis mouse model. Our findings suggest a possible role of IL-6 in oxidative stress defence and also give indication about an important function for Nrf2 in the regulation of hematopoietic and inflammatory processes.

Impact Factor

Scopus SNIP

Web of Science
Times Cited

Scopus
Cited By

Altmetric

5.328

1.333