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Open Access Green as soon as Postprint is submitted to ZB.
Prognostic significance of increased IL-10 production in patients prior to allogenic bone marrow transplantation.
Bone Marrow Transplant. 25, 237-241 (2000)
IL-10 is a potent immunosuppressant which inhibits allo-antigen-specific T cell responses. In addition, IL-10 is a strong endogenous anti-inflammatory cytokine. To investigate the role of IL-10 in the induction of acute GVHD following allogeneic bone marrow transplantation (BMT) we performed a prospective study on spontaneous IL-10 production by peripheral blood mononuclear cells (PBMNC) in 84 patients admitted for allogeneic BMT. High spontaneous IL-10 production by PBMNC at the time of admission and prior to any preparative treatment correlated with a subsequent low incidence of GVHD and transplant-related mortality (8%), as compared to patients with low or intermediate IL-10 production (50%, P < 0.01). Our data demonstrate the prognostic significance of increased IL-10 production in BMT patients and suggest a major role of IL-10 in maintaining immunobalance in the setting of allogeneic BMT.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
bone marrow transplantation IL-10 GVHD TNF-alpha
ISSN (print) / ISBN
0268-3369
e-ISSN
1476-5365
Journal
Bone Marrow Transplantation
Quellenangaben
Volume: 25,
Issue: 3,
Pages: 237-241
Publisher
Nature Publishing Group
Non-patent literature
Publications
Reviewing status
Peer reviewed