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Gehrmann, M.* ; Radons, J.* ; Molls, M.* ; Multhoff, G.

The therapeutic implications of clinically applied modifiers of heat shock protein 70 (Hsp70) expression by tumor cells.

Cell Stress Chaperones 13, 1-10 (2008)

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Open Access Green as soon as Postprint is submitted to ZB.

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Evidence that membrane-bound and extracellular heat shock proteins (HSPs) with molecular weights of 70 and 90 kDa are potent stimulators of the immune responses has accumulated over the last decade. In this review, we discuss the modulation of Hsp70 expression, a major stress-inducible member of the HSP70 family, in the cytoplasm and on the plasma membrane of tumor cells by clinically applied interventions such as radio- and chemotherapy.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Hsp70; Membrane expression; Stress response modifiers; NK cell; Tumor

ISSN (print) / ISBN 1355-8145

e-ISSN 1466-1268

Journal Cell Stress and Chaperones

Quellenangaben Volume: 13, Issue: 1, Pages: 1-10

Publisher Springer

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) CCG Innate Immunity in Tumor Biology (PATH-KTB)