Assessing the Impact of Classical Risk Factors on Myocardial Infarction by Rate Advancement Periods.
    
    
        
    
    
        
        Am. J. Epidemiol. 152, 884-888 (2000)
    
    
    
      
      
	
	    The risk or rate advancement period (RAP) proposed by Brenner et al. (Epidemiology 1993;4:229–36) conveys information on the impact of a risk factor on the age dimension of chronic disease occurrence and may thus facilitate communication of epidemiologic findings. The RAP expresses how much sooner a given risk or rate of disease occurrence is reached among exposed than among unexposed individuals. The purpose of the present analysis was to derive estimates of RAPs for cardiovascular risk factors in relation to incident nonfatal and fatal myocardial infarction in middle-aged men of the Monitoring Trends and Determinants in Cardiovascular Diseases (MONICA) Augsburg cohort, Germany, between 1984 and 1995. RAPs were estimated based on Cox proportional hazards models. After multivariate adjustment, hypertension, smoking, and dyslipidemia were associated with RAPs of 8, 11, and 11 years, respectively, conditional on infarction-free survival to baseline and absence of competing risks. The RAP may be interpreted as that, on average, smokers are expected to advance their risk of myocardial infarction approximately 11 years compared with never/former smokers; for example, 50-year-old smokers are expected to carry the same risk of infarction as 61-year-old nonsmokers. The authors encourage the use and evaluation of the RAP as an effective risk communication tool in actual counseling situations.
	
	
	    
	
       
      
	
	    
		Impact Factor
		Scopus SNIP
		Web of Science
Times Cited
		Scopus
Cited By
		Altmetric
		
	     
	    
	 
       
      
     
    
        Publication type
        Article: Journal article
    
 
    
        Document type
        Scientific Article
    
 
    
        Thesis type
        
    
 
    
        Editors
        
    
    
        Keywords
        cohort studies methods myocardial infarction risk
    
 
    
        Keywords plus
        
    
 
    
    
        Language
        english
    
 
    
        Publication Year
        2000
    
 
    
        Prepublished in Year
        
    
 
    
        HGF-reported in Year
        2000
    
 
    
    
        ISSN (print) / ISBN
        0002-9262
    
 
    
        e-ISSN
        1476-6256
    
 
    
        ISBN
        
    
    
        Book Volume Title
        
    
 
    
        Conference Title
        
    
 
	
        Conference Date
        
    
     
	
        Conference Location
        
    
 
	
        Proceedings Title
        
    
 
     
	
    
        Quellenangaben
        
	    Volume: 152,  
	    Issue: 9,  
	    Pages: 884-888 
	    Article Number: ,  
	    Supplement: ,  
	
    
 
    
        
            Series
            
        
 
        
            Publisher
            Oxford University Press
        
 
        
            Publishing Place
            
        
 
	
        
            Day of Oral Examination
            0000-00-00
        
 
        
            Advisor
            
        
 
        
            Referee
            
        
 
        
            Examiner
            
        
 
        
            Topic
            
        
 
	
        
            University
            
        
 
        
            University place
            
        
 
        
            Faculty
            
        
 
    
        
            Publication date
            0000-00-00
        
 
         
        
            Application date
            0000-00-00
        
 
        
            Patent owner
            
        
 
        
            Further owners
            
        
 
        
            Application country
            
        
 
        
            Patent priority
            
        
 
    
        Reviewing status
        Peer reviewed
    
 
    
        Institute(s)
        Institute of Epidemiology (EPI)
    
 
    
        POF-Topic(s)
        
30202 - Environmental Health
    
 
    
        Research field(s)
        
Genetics and Epidemiology
    
 
    
        PSP Element(s)
        G-503900-004
G-504090-001
    
 
    
        Grants
        
    
 
    
        Copyright
        
    
 	
    
    
        Erfassungsdatum
        2000-12-31