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Kreuzer, M. ; Müller, K.M.* ; Brachner, A. ; Gerken, M. ; Grosche, B. ; Wiethege, T.* ; Wichmann, H.-E.

Histopathologic Findings of Lung Carcinoma in German Uranium Miners.

Cancer Cytopathol. 89, 2613-2621 (2000)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
BACKGROUND: This study evaluates the histopathology of lung carcinoma in relation to underground radon exposure. METHODS: Two hundred forty uranium miners of the former Wismut Company in Eastern Germany with histologically or cytologically confirmed primary lung carcinoma were recruited from 3 study clinics between 1991 and 1995. Information on smoking history was obtained by personal interviews, whereas job histories were derived from original payrolls provided by the Wismut Company. Quantitative estimates of occupational radon exposure were based on a job-exposure matrix. RESULTS: Squamous cell carcinoma (SqCC) was the predominant cell type (43%), followed by adenocarcinoma (AC; 26%), small cell lung carcinoma (SCLC; 23%), and other cell types (8%). Nearly all patients were smokers. Time since first occupational exposure was 42 years on average, the mean cumulative radon exposure 506 working level months. Adenocarcinoma appeared to be more likely than both SCLC and SqCC among miners with low cumulative radiation exposure, long time since first exposure, an older age at diagnosis, and among ex- and never-smokers. In current smokers, lung carcinomas developed at a much lower level of radiation exposure than in ex- and never-smokers. The increase in the relative frequency of SCLC and SqCC at the expense of AC with increasing cumulative radiation exposure was more pronounced among ex- and never-smokers and seemed to be masked among current smokers. CONCLUSION: The authors' data suggest that all cell types were associated with radon exposure, but high radiation exposure tended to increase the proportion of SCLC and SqCC.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords lung carcinoma radon uranium mining histology smoking
ISSN (print) / ISBN 1934-662X
e-ISSN 1097-0142
Journal Cancer Cytopathology
Quellenangaben Volume: 89, Issue: 12, Pages: 2613-2621 Article Number: , Supplement: ,
Publisher Wiley
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)