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Clinical and Immunological Features of Patients with Interleukin-5-Producing T Cell Clones and Eosinophilia.
Int. Arch. Allergy Immunol. 124, 242-245 (2001)
Recent work suggests that in some patients with the hypereosinophilic syndrome, a clone of abnormal T cells produces large amounts of interleukin-5. In this study, we examined 60 patients with idiopathic eosinophilia. Sixteen patients had circulating T cells with an aberrant immunophenotype that, in most cases, were associated with different forms of skin inflammation. The abnormal T cells produced large amounts of interleukin-5, which may have increased eosinophil differentiation in the bone marrow of these patients.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Clonal T cells Eosinophils Hypereosinophilia Immunophenotype Interleukin-5
ISSN (print) / ISBN
1018-2438
e-ISSN
1423-0097
Quellenangaben
Volume: 124,
Issue: 1-3,
Pages: 242-245
Publisher
Karger
Publishing Place
Basel ; Freiburg [Breisgau] ; Paris ; London ; New York ; Bangalore ; Bangkok ; Singapore ; Tokyo ; Sydney
Reviewing status
Peer reviewed
Institute(s)
Institute of Lung Health and Immunity (LHI)