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Simon, H.-U.* ; Plötz, S.G. ; Simon, D.* ; Dummer, R.* ; Blaser, K.*

Clinical and Immunological Features of Patients with Interleukin-5-Producing T Cell Clones and Eosinophilia.

Int. Arch. Allergy Immunol. 124, 242-245 (2001)

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Open Access Green as soon as Postprint is submitted to ZB.

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Recent work suggests that in some patients with the hypereosinophilic syndrome, a clone of abnormal T cells produces large amounts of interleukin-5. In this study, we examined 60 patients with idiopathic eosinophilia. Sixteen patients had circulating T cells with an aberrant immunophenotype that, in most cases, were associated with different forms of skin inflammation. The abnormal T cells produced large amounts of interleukin-5, which may have increased eosinophil differentiation in the bone marrow of these patients.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Clonal T cells Eosinophils Hypereosinophilia Immunophenotype Interleukin-5

ISSN (print) / ISBN 1018-2438

e-ISSN 1423-0097

Journal International Archives of Allergy and Immunology

Quellenangaben Volume: 124, Issue: 1-3, Pages: 242-245

Publisher Karger

Publishing Place Basel ; Freiburg [Breisgau] ; Paris ; London ; New York ; Bangalore ; Bangkok ; Singapore ; Tokyo ; Sydney

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Lung Health and Immunity (LHI)