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Müller, T.D.* ; Brönner, G.* ; Wandolski, M.* ; Carrie, J.* ; Nguyen, T.T.* ; Greene, B.H.* ; Scherag, A.* ; Grallert, H. ; Vogel, C.I.G.* ; Scherag, S.* ; Rief, W.* ; Wichmann, H.-E. ; Illig, T. ; Schäfer, H.* ; Hebebrand, J.* ; Hinney, A.*

Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity.

BMC Med. Genet. 11:2 (2010)
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BACKGROUND: The orexigenic effects of cannabinoids are limited by activation of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH). The aim of this study was to analyse whether FAAH alleles are associated with early and late onset obesity. METHODS: We initially assessed association of five single nucleotide polymorphisms (SNPs) in FAAH with early onset extreme obesity in up to 521 German obese children and both parents. SNPs with nominal p-values 0.05). CONCLUSIONS: As we observed some evidence for an association of the FAAH variants rs2295632 rs324420 with early onset but not adult obesity, we conclude that the FAAH variants analyzed here at least do not seem to play a major role in the etiology of obesity within our samples.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Problem drug-use; Endocannabinoid system; Disequilibrium test; Extreme obesity; Anadamide; Polymorphism; Metabolism; Variants; Linkage; Brain
Language english
Publication Year 2010
HGF-reported in Year 2010
e-ISSN 1471-2350
Journal BMC Medical Genetics
Quellenangaben Volume: 11, Issue: 1, Pages: , Article Number: 2 Supplement: ,
Publisher BioMed Central Ltd.
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
CCG Nutrigenomics and Type 2 Diabetes (KKG-KDN)
Research Unit Molecular Epidemiology (AME)
Institute of Diabetes and Obesity (IDO)
POF-Topic(s) 30503 - Chronic Diseases of the Lung and Allergies
30502 - Diabetes: Pathophysiology, Prevention and Therapy
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health

30202 - Environmental Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-503900-003
G-521600-002
G-503900-001
G-504200-001
G-504090-001
PubMed ID 20044928
DOI 10.1186/1471-2350-11-2
WOS ID 000275340200001
Scopus ID 77649098597
Erfassungsdatum 2010-09-20
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