PuSH - Publication Server of Helmholtz Zentrum München

Nimmerjahn, F. ; Milosevic, S. ; Behrends, U. ; Jaffee, E.M.* ; Pardoll, D.M.* ; Bornkamm, G.W. ; Mautner, J.

Major histocompatibility complex class II-restricted presentation of a cytosolic antigen by autophagy.

Eur. J. Immunol. 33, 1250-1259 (2003)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
Biochemical and functional studies have demonstrated major histocompatibility complex (MHC) class II-restricted presentation of peptides derived from cytosolic proteins, but the underlying processing and presentation pathways have remained elusive. Here we show that endogenous presentation of an epitope derived from the cytosolic protein neomycin phosphotransferase II (NeoR) on MHC classII is mediated by autophagy. This presentation pathway involves the sequestration of NeoR into autophagosomes, and subsequent delivery into the lytic compartment. These results identify endosomes/lysosomes as the processing compartment for cytosolic antigens and furthermore link endogenous antigen presentation on MHC class II with the process of cellular protein turnover by autophagy.
Altmetric
Additional Metrics?
[➜Log in]
Edit extra informations Login
Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Antigen presentation Human MHC T lymphocyte
ISSN (print) / ISBN 0014-2980
e-ISSN 1521-4141
Journal European Journal of Immunology
Quellenangaben Volume: 33, Issue: 5, Pages: 1250-1259 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place Hoboken
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Clinical Molecular Biology and Tumor Genetics (K.MOLBI)