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Open Access Green as soon as Postprint is submitted to ZB.
Major histocompatibility complex class II-restricted presentation of a cytosolic antigen by autophagy.
Eur. J. Immunol. 33, 1250-1259 (2003)
Biochemical and functional studies have demonstrated major histocompatibility complex (MHC) class II-restricted presentation of peptides derived from cytosolic proteins, but the underlying processing and presentation pathways have remained elusive. Here we show that endogenous presentation of an epitope derived from the cytosolic protein neomycin phosphotransferase II (NeoR) on MHC classII is mediated by autophagy. This presentation pathway involves the sequestration of NeoR into autophagosomes, and subsequent delivery into the lytic compartment. These results identify endosomes/lysosomes as the processing compartment for cytosolic antigens and furthermore link endogenous antigen presentation on MHC class II with the process of cellular protein turnover by autophagy.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Antigen presentation Human MHC T lymphocyte
ISSN (print) / ISBN
0014-2980
e-ISSN
1521-4141
Journal
European Journal of Immunology
Quellenangaben
Volume: 33,
Issue: 5,
Pages: 1250-1259
Publisher
Wiley
Publishing Place
Hoboken
Reviewing status
Peer reviewed