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Open Access Green as soon as Postprint is submitted to ZB.
Dendritic Cells under Influence of Mouse Cytomegalovirus Have a Physiologic Dual Role : To Initiative and to Restrict T Cell Activation.
J. Infect. Dis. 187, 988-999 (2003)
The aim of this study is to analyze the dynamics of the mouse cytomegalovirus (MCMV)-dendritic cell (DC) interaction. Immature and mature DCs derived from the mouse stem cell line factor-dependent cell Paterson mixed potential were infected with a recombinant MCMV expressing green fluorescent protein. Infection of immature DCs resulted in DC activation and virus production, both of which may contribute to viral dissemination. The infection of mature DCs was nonproductive and was restricted to immediate-early and early viral protein expression. During early stages of MCMV infection, mature DCs up-regulated major histocompatibility complex (MHC) and costimulatory molecules and activated autologous, but not allogeneic, naive T cells. At later times of MCMV infection, DCs prevented T cell activation by down-regulation of MHC and costimulatory molecules. Thus, DCs under the influence of MCMV have a physiologic dual role: to initiate and to restrict T cell activation. The lack of immunostimulation in allogeneic settings may explain the increased risk of MCMV morbidity after allogeneic transplantation.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
BONE-MARROW TRANSPLANTATION; SIMPLEX VIRUS TYPE-1; CLASS-II EXPRESSION; MURINE CYTOMEGALOVIRUS; HERPESVIRUS GENOME; CROSS-PRESENTATION; IMMUNE-RESPONSE; GLYCOPROTEIN-B; PP65 UL83; INFECTION
ISSN (print) / ISBN
0022-1899
e-ISSN
1537-6613
Quellenangaben
Volume: 187,
Issue: 6,
Pages: 988-999
Publisher
Oxford University Press
Non-patent literature
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Reviewing status
Peer reviewed