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Open Access Green as soon as Postprint is submitted to ZB.
Gene expression in the liver of Long-Evans cinnemon rats during the development of hepatitis.
Arch. Toxicol. 77, 568-575 (2003)
The Long-Evans cinnamon (LEC) rat, an authentic model for Wilson disease, is characterized by a mutation in the Atp7b gene leading to a defective copper excretion and, as a consequence, to an accumulation of the metal in the liver and copper-associated hepatotoxicity. In the present communication expression profiles of genes in the liver from wild-type Long-Evans agouti (LEA) and LEC rats at different stages of copper accumulation and liver disease were investigated. Disease states were defined according to serum aspartate aminotransferase activity and bilirubin levels in serum and from histopathology of the liver. Gene expression was determined with the Affymetrix RTU34 oligonucleotide array covering 1031 genes. Compared to the LEA rat, the nondiseased LEC rat with already increased hepatic copper level showed an enhanced expression of genes, particularly related to oxidative stress and DNA damage. During the progression of the liver disease, in particular genes related to oxidative stress, DNA damage, apoptosis and inflammation with acute-phase reaction were upregulated.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Long-Evans cinnamon rat Long-Evans agouti rat Gene expression Copper Oligonucleotide array
ISSN (print) / ISBN
0340-5761
e-ISSN
1432-0738
Journal
Archives of Toxicology
Quellenangaben
Volume: 77,
Issue: 10,
Pages: 568-575
Publisher
Springer
Non-patent literature
Publications
Reviewing status
Peer reviewed