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Schneider, M.R.* ; Gratao, A.A.* ; Dahlhoff, M.* ; Boersma, A. ; Hrabě de Angelis, M. ; Hoang-Vu, C.* ; Wolf, E.* ; Klonisch, T.*

EGFR ligands exert diverging effects on male reproductive organs.

Exp. Mol. Pathol. 88, 216-218 (2010)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
While the EGFR and most of its ligands are expressed in the male reproductive tract, their functions in male reproduction are poorly understood. Interestingly, male transgenic mice overexpressing EGF are sterile, and transgenic mice overexpressing TGFA, another EGFR ligand, show an enlarged coagulation gland (anterior prostate) due to severe hyperplasia with focal dysplasia. We studied the male reproductive tract of transgenic mice overexpressing betacellulin (BTC-tg) under the control of a promoter conferring widespread transgene expression. Despite strong overexpression of BTC in different parts of the male reproductive tract, the gross appearance and histology of the reproductive organs of BTC-tg males were normal and the same were true for sperm parameters and the in vitro fertilization rate. Collectively, our findings demonstrate that excess of BTC exerts no deleterious effects on the structure or function of the male reproductive tract in mice and indicates unique, non-overlapping functions of specific EGFR ligands in male reproduction.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Epidermal growth factor; EGFR; Betacellulin; Transgenic mice; Male reproductive tract
Language english
Publication Year 2010
HGF-reported in Year 2010
ISSN (print) / ISBN 0014-4800
e-ISSN 0014-4800
Journal Experimental and Molecular Pathology
Quellenangaben Volume: 88, Issue: 1, Pages: 216-218 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) Institute of Experimental Genetics (IEG)
POF-Topic(s) 30201 - Metabolic Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-500600-003
PubMed ID 19931240
DOI 10.1016/j.yexmp.2009.11.005
Scopus ID 75049085854
Erfassungsdatum 2010-04-07
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