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von Boehmer, H.* ; Daniel, C.

Therapeutic opportunities for manipulating TReg cells in autoimmunity and cancer.

Nat. Rev. Drug Discov. 12, 51-63 (2013)
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Forkhead box P3 (FOXP3)-expressing regulatory T (T-Reg) cells have a pivotal role in the regulation of immune responses and in the maintenance of immunological self-tolerance. These cells have emerged as attractive targets for strategies that allow the steering of immune responses in desired directions-arming the immune system to destroy infected cells and cancer cells or downregulating it to limit tissue destruction in autoimmunity. Efforts to understand the generation, activation and function of T-Reg cells should permit the development of therapeutics for reprogramming the immune system. In this Review, we discuss insights into the generation of T-Reg cells, their involvement in disease and the molecular basis of the dominant tolerance exerted by FOXP3(+) T-Reg cells that could permit their safe and specific manipulation in humans.
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Publication type Article: Journal article
Document type Review
Keywords Versus-host-disease ; Ligase Cbl-b ; Nf-kappa-b ; In-vivo ; Foxp3 Expression ; Regulatory Cells ; Immune-response ; Nod Mice ; Antitumor Immunity ; Peripheral-blood
Language english
Publication Year 2013
HGF-reported in Year 2013
ISSN (print) / ISBN 1474-1776
Journal Nature Reviews - Drug Discovery
Quellenangaben Volume: 12, Issue: 1, Pages: 51-63 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research (IDF)
POF-Topic(s) 30502 - Diabetes: Pathophysiology, Prevention and Therapy
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-552200-002
PubMed ID 23274471
DOI 10.1038/nrd3683
WOS ID WOS:000312987000015
Erfassungsdatum 2013-02-01
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