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Open Access Green as soon as Postprint is submitted to ZB.
Multispectral photoacoustic imaging of fluorochromes in small animals.
Opt. Lett. 32, 2891-2893 (2007)
Fluorochromes have become essential reporter molecules in biological research. We show that the depth-resolved distribution of fluorochromes in small animals can be imaged with 25 fmol sensitivity and 150 microm spatial resolution by means of multispectral photoacoustic imaging. The major advantage of the multispectral approach is the sensitive differentiation of chromophores and fluorochromes of interest based on self-reference measurements, as evidenced in this study by resolving a commonly used fluorochrome (Alexa Fluor 750) in mouse. The suggested method is well suited for enhancing visualization of functional and molecular information in vivo and longitudinally.
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Publication type
Article: Journal article
Document type
Scientific Article
Language
english
Publication Year
2007
HGF-reported in Year
0
ISSN (print) / ISBN
0146-9592
e-ISSN
1539-4794
Journal
Optics Letters
Quellenangaben
Volume: 32,
Issue: 19,
Pages: 2891-2893
Publisher
Optical Society of America (OSA)
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)
PubMed ID
17909608
Erfassungsdatum
2007-12-31