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Identification and functional modelling of DNA sequence elements of transcription.
Brief. Bioinform. 1, 372-380 (2000)
Identification of transcriptional elements in large sequences is a very difficult task, as individual transcription elements (eg transcription factor binding sites,TF-sites) are not clearly correlated with regions exerting transcription control. However, elucidation of the molecular organisation of genomic regions responsible for the control of gene expression is an essential part of the efforts to annotate the genomic sequences, especially within the Human Genome Project. The task for bioinformatics in this context is twofold. The first step required is the approximate localisation of regulatory sequences in large anonymous DNA sequences. Once those regions are located, the second task is the identification of individual transcriptional control elements and correlation of a subset of such elements with transcriptional functions. Part of this second task can be achieved by constructing organisational models of regulatory regions like promoters which can reveal elements important for a gene class or the coexpression of a set of genes. Comparative genomics in non-coding regions (eg phylogenetic footprinting) is a very promising approach that allows identification of potential new regulatory elements which may be used in modelling approaches.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
DNA sequence; genome analysis; promoter; transcription control
Language
english
Publication Year
2000
HGF-reported in Year
0
ISSN (print) / ISBN
1467-5463
e-ISSN
1477-4054
Journal
Briefings in Bioinformatics
Quellenangaben
Volume: 1,
Issue: 4,
Pages: 372-380
Publisher
Oxford University Press
Reviewing status
Peer reviewed
Institute(s)
Institute of Experimental Genetics (IEG)
POF-Topic(s)
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Research field(s)
Genetics and Epidemiology
PSP Element(s)
G-500600-002
Erfassungsdatum
2004-12-31