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Justice, M.J.* ; Carpenter, D.A.* ; Favor, J. ; Neuhäuser-Klaus, A. ; Hrabě de Angelis, M. ; Soewarto, D. ; Moser, A.* ; Cordes, S.* ; Miller, D.* ; Chapman, V.* ; Weber, J.S.* ; Rinchik, E.M.* ; Hunsicker, P.R.* ; Russell, W.L.* ; Bode, V.C.*

Effects of ENU dosage on mouse strains.

Mamm. Genome 11, 484-488 (2000)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
The germline supermutagen, N-ethyl-N-nitrosourea (ENU), has a variety of effects on mice. ENU is a toxin and carcinogen as well as a mutagen, and strains differ in their susceptibility to its effects. Therefore, it is necessary to determine an appropriate mutagenic, non-toxic dose of ENU for strains that are to be used in experiments. In order to provide some guidance, we have compiled data from a number of laboratories that have exposed male mice from inbred and non-inbred strains or their F(1) hybrids to ENU. The results show that most F(1) hybrid animals tolerate ENU well, but that inbred strains of mice vary in their longevity and in their ability to recover fertility after treatment with ENU.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
ISSN (print) / ISBN 0938-8990
e-ISSN 1432-1777
Journal Mammalian Genome
Quellenangaben Volume: 11, Issue: 7, Pages: 484-488 Article Number: , Supplement: ,
Publisher Springer
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Experimental Genetics (IEG)