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Open Access Green as soon as Postprint is submitted to ZB.
Hourly variation in fine particle exposure is associated with transiently increased risk of ST segment depression.
Occup. Environ. Med. 65, 782-786 (2008)
Objectives: To evaluate whether hourly changes in fine particle (PM2.5, diameter, <2.5 mu m) exposure or outdoor particle concentrations are associated with rapid ischaemic responses. Methods: 41 non-smoking elderly people with coronary heart disease were followed up with biweekly clinic visits in Helsinki, Finland. The occurrence of ST segment depressions >0.1 mV was recorded during submaximal exercise tests. Hourly variations in personal PM2.5 exposure and outdoor levels of PM2.5 and ultrafine particles (<0.1 mu m) were recorded for 24 h before a clinic visit. Associations between particulate air pollution and ST segment depressions were evaluated using logistic regression. Results: Both personal and outdoor PM2.5 concentrations, but not outdoor ultrafine particle counts, were associated with ST segment depressions. The odds ratio (per 10 mu g/m(3)) for personal PM2.5 concentration during the hour preceding a clinic visit was 3.26 (95% CI 1.07 to 9.99) and for 4 h average outdoor PM2.5 it was 2.47 (95% CI 1.05 to 5.85). Conclusions: Even very short-term elevations in fine particle exposure might increase the risk of myocardial ischaemia. The precise mechanism is still unknown but could involve changes in autonomic nervous control of the heart.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
coronary-heart-disease; particulate air-pollution; elderly subjects; myocardial-infarction; rate-variability; ultrafine particles; inflammation; mortality; markers; matter
Language
english
Publication Year
2008
HGF-reported in Year
2008
ISSN (print) / ISBN
1351-0711
e-ISSN
1470-7926
Quellenangaben
Volume: 65,
Issue: 11,
Pages: 782-786
Publisher
BMJ Publishing Group
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology (EPI)
PSP Element(s)
G-503900-005
Scopus ID
55349143196
Erfassungsdatum
2008-12-31