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Open Access Green as soon as Postprint is submitted to ZB.
Extra-thymically induced regulatory T cells: do they have potential in disease prevention?
Semin. Immunol. 23, 410-417 (2011)
Fopx3(+) Treg safeguard against autoimmune diseases and immune pathology. The extrathymic conversion of naïve T cells into Foxp3(+) regulatory T cells can be achieved in vivo by the delivery of strong-agonist ligands under subimmunogenic conditions. Tolerogenic vaccination with strong-agonist mimetopes of self-antigen to promote self-antigen specific tolerance may represent the most specific and safest means of preventing autoimmunity. This review discusses the requirements for induction of dominant tolerance exerted by Foxp3(+) Tregs in autoimmunity with special emphasis on their impact to interfere with T1D. The future goals are the understanding of self-non-self discrimination at the cellular and molecular level, which should then enable investigators to develop clinical vaccination protocols that specifically interfere with unwanted immune responses.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
1044-5323
e-ISSN
1044-5323
Journal
Seminars in Immunology
Quellenangaben
Volume: 23,
Issue: 6,
Pages: 410-417
Publisher
Elsevier
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes Research (IDF)