PuSH - Publication Server of Helmholtz Zentrum München

Nolting, J.* ; Daniel, C.* ; Reuter, S.* ; Stuelten, C.* ; Li, P.* ; Sucov, H.* ; Kim, B.G.* ; Letterio, J.J.* ; Kretschmer, K.* ; Kim, H.J.* ; von Boehmer, H.*

Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines.

J. Exp. Med. 206, 2131-2139 (2009)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
It has been reported that retinoic acid (RA) enhances regulatory T (T reg) cell conversion by inhibiting the secretion of cytokines that interfere with conversion. This report shows that these conclusions provide a partial explanation at best. First, RA not only interfered with cytokine secretion but also with the ability of these cytokines to inhibit T reg cell conversion of naive T cells. Furthermore, RA enhanced conversion even in the absence of inhibitory cytokines. The latter effect depended on the RA receptor alpha (RAR alpha) but did not require Smad3, despite the fact that RA enhanced Smad3 expression. The RAR alpha 1 isoform was not essential for RA-dependent enhancement of transforming growth factor beta-driven conversion, suggesting that conversion can also be mediated by RAR alpha 2. Interleukin (IL)-6 strongly reduced RAR alpha expression levels such that a deficiency of the predominant RAR alpha 1 isoform leaves too little RAR alpha 2 for RA to inhibit the generation of Th17 cells in the presence of IL-6.
Altmetric
Additional Metrics?
[➜Log in]
Edit extra informations Login
Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 0022-1007
e-ISSN 1540-9538
Journal Journal of Experimental Medicine
Quellenangaben Volume: 206, Issue: 10, Pages: 2131-2139 Article Number: , Supplement: ,
Publisher Rockefeller University Press
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research (IDF)