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Mayer, B.* ; Lieb, W.* ; Götz, A.* ; König, I.R.* ; Kauschen, L.F.* ; Linsel-Nitschke, P.* ; Pomarino, A.* ; Holmer, S.* ; Hengstenberg, C.* ; Döring, A. ; Loewel, H. ; Hense, H.W.* ; Ziegler, A.* ; Erdmann, J.* ; Schunkert, H.*

Association of a functional polymorphism in the CYP4A11 gene with systolic blood pressure in survivors of myocardial infarction.

J. Hypertens. 24, 1965-1970 (2006)

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Open Access Green as soon as Postprint is submitted to ZB.

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OBJECTIVE: Survivors of myocardial infarction (MI) are known to have a high prevalence of arterial hypertension which, at the same time, imposes a major risk to such patients. Genetic variants of the arachidonic acid monooxygenase CYP4A11 may result in decreased synthesis of 20-hydroxyeicostatetraenoic acid (20-HETE), experimental hypertension and elevated blood pressure levels in humans. The present study aimed to investigate the impact of the functionally relevant T8590C polymorphism of this gene on blood pressure and the prevalence of hypertension in MI patients. METHODS: Survivors of MI from the MONICA Augsburg MI registry (n = 560) were studied after a mean of 5.6 years after the acute event. Participants were examined by standardized anthropometric and echocardiographic measurements, as well as genotyping for CYP4A11 T8590C allele status. RESULTS: Genotype frequencies in MI patients (TT = 71.8%, CT = 26.2%, CC = 2.0%) did not differ from those in population-based controls (n = 1363; TT = 75.4%, CT = 22.5% and CC = 2.1%, P = 0.22). MI survivors with the CC genotype displayed higher systolic blood pressure levels (CC: 143.4 ± 4.9 mmHg versus CT: 134.5 ± 1.3 mmHg and TT: 131.1 ± 0.8 mmHg; P = 0.02) and a non-significant trend towards higher diastolic blood pressure levels (CC: 88.4 ± 3.0 mmHg versus CT: 84.9 ± 0.8 mmHg and TT: 83.9 ± 0.5 mmHg; P = 0.17) in multivariate models. Accordingly, the C allele was related to elevated odds ratios for hypertension in a recessive [4.14; 95% confidence interval (CI) = 1.07-15.96, P = 0.04] and in a dominant model (1.50; 95% CI = 1.03-2.20, P = 0.04), respectively. No blood pressure-independent association of the T8590C polymorphism with echocardiographic parameters of left ventricular function and/or geometry was found. CONCLUSION: The data obtained in the present study strengthen the evidence of an association of the CYP4A11 T8590C polymorphism with blood pressure levels and hypertension prevalence. Particularly, the risk of arterial hypertension is substantially higher in MI patients homozygous for the CC allele. By contrast, no evidence was obtained for an association between this genotype and MI. © 2006 Lippincott Williams & Wilkins.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords association; CYP4A11; genetics; hypertension; left ventricular structure; myocardial infarction; polymorphism

ISSN (print) / ISBN 0263-6352

e-ISSN 1473-5598

Journal Journal of Hypertension

Quellenangaben Volume: 24, Issue: 10, Pages: 1965-1970

Publisher Lippincott Williams & Wilkins

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Epidemiology (EPI)