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Canis, M.* ; Lechner, A.* ; Mack, B.* ; Zengel, P.* ; Laubender, R.P.* ; Koehler, U.* ; Heissmeyer, V. ; Gires, O.

CD133 is a predictor of poor survival in head and neck squamous cell carcinomas.

Cancer Biomark. 12, 97-105 (2012)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
BACKGROUND: The pentaspan protein CD133 (Prominin-1) is a predictive marker and part of the signature of tumour-initiating cells (TICs) for various cancer entities. METHODS: The correlation of CD133 expression with clinical parameters was assessed in primary samples of head and neck squamous cell carcinomas (n = 98) and normal mucosas (n = 24). RESULTS: A gradual and inversely proportional correlation between CD133 expression in primary tumours and decreased overall survival was observed, along with a positive correlation with the presence of lymph node metastases. CONCLUSIONS: CD133 has the potential of being a novel clinically relevant prognostic marker for head and neck malignancies, which is possibly involved in regulation of tumourigenicity.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Cd133 ; Hnsccs ; Overall Survival; Node-positive Head ; Cancer Stem-cells ; Adjuvant Radiotherapy ; Oropharyngeal Cancer ; Epidemiology ; Expression ; Protein ; Alpha
Language english
Publication Year 2012
HGF-reported in Year 2013
ISSN (print) / ISBN 1574-0153
e-ISSN 1875-8592
Journal Cancer Biomarkers
Quellenangaben Volume: 12, Issue: 2, Pages: 97-105 Article Number: , Supplement: ,
Publisher IOS Press
Reviewing status Peer reviewed
Institute(s) Research Unit Gene Vector (AGV)
Institute of Molecular Immunology (IMI)
POF-Topic(s) 30203 - Molecular Targets and Therapies
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Immune Response and Infection
PSP Element(s) G-501500-001
G-501792-001
PubMed ID 23396254
DOI 10.3233/CBM-130297
WOS ID WOS:000314831300005
Scopus ID 84874320496
Erfassungsdatum 2013-03-07
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