PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Corradi, A.* ; Croci, L.* ; Broccoli, V.* ; Zecchini, S.* ; Previtali, S.* ; Wurst, W. ; Amadio, S.* ; Maggi, R.* ; Quattrini, A.* ; Consalez, G.G.*

Hypogonadotropic hypogonadism and peripheral neuropathy in Ebf2-null mice.

Development 130, 401-410 (2003)
Publ. Version/Full Text DOI
Closed
Open Access Green as soon as Postprint is submitted to ZB.
Olf/Ebf transcription factors have been implicated in numerous developmental processes, ranging from B-cell development to neuronal differentiation. We describe mice that carry a targeted deletion within the EbJ2 (O/E3) gene. In Ebf2-null mutants, because of defective migration of gonadotropin releasing hormone-synthesizing neurons, formation of the neuroendocrine axis (which is essential for pubertal development) is impaired, leading to secondary hypogonadism. In addition, Ebf2(-/-) peripheral nerves feature defective axon sorting, hypomyelination, segmental dysmyelination and axonal damage, accompanied by a sharp decrease in motor nerve conduction velocity. Ebf2-null mice reveal a novel genetic cause of hypogonadotropic hypogonadism and peripheral neuropathy in the mouse, disclosing an important role for Ebf2 in neuronal migration and nerve development.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
7.883
0.000
69
82
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords Olf/Ebf genes; Neurogenesis; Neural development; Neuronal migration; Neuroendocrine; GnRH neurons; Peripheral nerve; Peripheral neuropathy; Dysmyelination; Gene targeting; COE2; O/E3
Language english
Publication Year 2003
HGF-reported in Year 0
ISSN (print) / ISBN 0950-1991
e-ISSN 1477-9129
Journal Development / Company of Biologists
Quellenangaben Volume: 130, Issue: 2, Pages: 401-410 Article Number: , Supplement: ,
Publisher Company of Biologists
Reviewing status Peer reviewed
Institute(s) Institute of Developmental Genetics (IDG)
POF-Topic(s) 30204 - Cell Programming and Repair
Research field(s) Genetics and Epidemiology
PSP Element(s) G-500500-001
DOI 10.1242/dev.00215
Scopus ID 0037265734
Erfassungsdatum 2004-03-03
[➜Report correction]