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Open Access Green as soon as Postprint is submitted to ZB.
Hypogonadotropic hypogonadism and peripheral neuropathy in Ebf2-null mice.
Development 130, 401-410 (2003)
Olf/Ebf transcription factors have been implicated in numerous developmental processes, ranging from B-cell development to neuronal differentiation. We describe mice that carry a targeted deletion within the EbJ2 (O/E3) gene. In Ebf2-null mutants, because of defective migration of gonadotropin releasing hormone-synthesizing neurons, formation of the neuroendocrine axis (which is essential for pubertal development) is impaired, leading to secondary hypogonadism. In addition, Ebf2(-/-) peripheral nerves feature defective axon sorting, hypomyelination, segmental dysmyelination and axonal damage, accompanied by a sharp decrease in motor nerve conduction velocity. Ebf2-null mice reveal a novel genetic cause of hypogonadotropic hypogonadism and peripheral neuropathy in the mouse, disclosing an important role for Ebf2 in neuronal migration and nerve development.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Olf/Ebf genes; Neurogenesis; Neural development; Neuronal migration; Neuroendocrine; GnRH neurons; Peripheral nerve; Peripheral neuropathy; Dysmyelination; Gene targeting; COE2; O/E3
ISSN (print) / ISBN
0950-1991
e-ISSN
1477-9129
Quellenangaben
Volume: 130,
Issue: 2,
Pages: 401-410
Publisher
Company of Biologists
Reviewing status
Peer reviewed
Institute(s)
Institute of Developmental Genetics (IDG)