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Open Access Green as soon as Postprint is submitted to ZB.
Analyzing cell fate control by cytokines through continuous single cell biochemistry.
J. Cell. Biochem. 108, 343-352 (2009)
Cytokines are important regulators or cell fates with high clinical and commercial relevance. However, despite decades of intense academic and industrial research, it proved surprisingly difficult to describe the biological functions of cytokines in a precise and comprehensive manner. The exact analysis of cytokine biology is complicated by the fact that. individual cytokines control many different cell fates and activate a multitude of intracellular signaling pathways. Moreover, although activating different molecular programs, different cytokines can be redundant in their biological effects. In addition, cytokines with different biological effects can activate overlapping signaling pathways. This prospect article will outline the necessity of continuous single cell biochemistry to unravel the biological functions of molecular cytokine signaling. It focuses on potentials and limitations of recent technical developments in fluorescent time-lapse imaging and single cell tracking allowing constant long-term observation of molecules and behavior of single cells.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
HEMATOPOIESIS; CYTOKINE SIGNALING; TIME-LAPSE IMAGING; SINGLE CELL TRACKING; FRET; COLONY-STIMULATING FACTOR; PROTEIN-KINASE-C; LIVING CELLS; HEMATOPOIETIC CYTOKINES; FLUORESCENT INDICATORS; LINEAGE COMMITMENT; PLASMA-MEMBRANE; RECEPTOR; ACTIVATION; MACROPHAGE
ISSN (print) / ISBN
0730-2312
e-ISSN
1097-4644
Journal
Journal of Cellular Biochemistry
Quellenangaben
Volume: 108,
Issue: 2,
Pages: 343-352
Publisher
Wiley
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Stem Cell Research (ISF)