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Atad3 function is essential for early post-implantation development in the mouse.
PLoS ONE 8:e54799 (2013)
The mitochondrial AAA+-ATPase ATAD3 is implicated in the regulation of mitochondrial and ER dynamics and was shown to be necessary for larval development in Caenorhabditis elegans. In order to elucidate the relevance of ATAD3 for mammalian development, the phenotype of an Atad3 deficient mouse line was analyzed. Atad3 deficient embryos die around embryonic day E7.5 due to growth retardation and a defective development of the trophoblast lineage immediately after implantation into the uterus. This indicates an essential function of Atad3 for the progression of the first steps of post-implantation development at a time point when mitochondrial biogenesis and ATP production by oxidative phosphorylation are required. Therefore, murine Atad3 plays an important role in the biogenesis of mitochondria in trophoblast stem cells and in differentiating trophoblasts. At the biochemical level, we report here that ATAD3 is present in five native mitochondrial protein complexes of different sizes, indicating complex roles of the protein in mitochondrial architecture and function.
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Scopus SNIP
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Times Cited
Times Cited
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3.730
1.148
32
32
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Embryonic Stem-cells ; M-aaa Protease ; Mitochondrial Fusion ; Mammalian-cells ; Molecular Characterization ; Cristae Morphogenesis ; Endoplasmic-reticulum ; Antioxidant Enzymes ; Cancer-cells ; C-elegans
Language
english
Publication Year
2013
HGF-reported in Year
2013
ISSN (print) / ISBN
1932-6203
Journal
PLoS ONE
Quellenangaben
Volume: 8,
Issue: 1,
Article Number: e54799
Publisher
Public Library of Science (PLoS)
Publishing Place
Lawrence, Kan.
Reviewing status
Peer reviewed
Institute(s)
Institute of Molecular Immunology (IMI)
POF-Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s)
Immune Response and Infection
PSP Element(s)
G-501793-001
PubMed ID
23372768
WOS ID
WOS:000315210400030
Scopus ID
84872831460
Erfassungsdatum
2013-03-21