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Koch, W.* ; Mehilli, J.* ; Pfeufer, A. ; Schömig, A.* ; Kastrati, A.*

Apolipoprotein E gene polymorphisms and thrombosis and restenosis after coronary artery stenting.

J. Lipid Res. 45, 2221-2226 (2004)
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Experimental data support a protective function of apolipoprotein E (apoE) against restenosis, the main factor limiting the long-term benefit of percutaneous coronary interventions. We investigated the possibility that the single nucleotide polymorphisms (SNPs) -219G/T, 113G/C, 334T/C, and 472C/T of the gene encoding apoE (APOE) are associated with the incidence of death and myocardial infarction or restenosis after stenting in coronary arteries. In addition, we asked whether the apoE isotype-related epsilon2/epsilon3/epsilon4 polymmorphism, defined by specific allele combinations (haplotypes) of the 334T/C and 472C/T polymorphism, and other APOE haplotypes, derived from all four SNPs investigated, are associated with adverse clinical and angiographic outcomes after stenting. Our study included 1,850 consecutive patients with symptomatic coronary artery disease (CAD) who underwent stent implantation. Follow-up angiography was performed in 1,556 patients (84.1%) at 6 months after the intervention. We found that none of the APOE SNPs is associated with death and myocardial infarction or restenosis after stenting. In addition, we observed no relationship between APOE haplotypes and adverse outcomes. In conclusion, the APOE -219G/T, 113G/C, 334T/C, and 472C/T polymorphisms, either alone or in combination, do not represent genetic markers of the risk of thrombotic and restenotic complications in patients with CAD treated with coronary stenting. Koch, W.J. Mehilli, A. Pfeufer, A. Schomig, and A. Kastrati. Apolipoprotein E gene polymorphisms and thrombosis and restenosis after coronary artery stenting.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords coronary artery disease; APOE epsilon alleles; APOE haplotypes; TaqMan genotyping; E-DEFICIENT MICE; MYOCARDIAL-INFARCTION; EPSILON-4 ALLELE; TISSUE-RESPONSE; ANGIOPLASTY; DISEASE; RISK; ASSOCIATION; ATHEROSCLEROSIS; FREQUENCIES
ISSN (print) / ISBN 0022-2275
e-ISSN 1539-7262
Journal Journal of Lipid Research
Quellenangaben Volume: 45, Issue: 12, Pages: 2221-2226 Article Number: , Supplement: ,
Publisher American Society for Biochemistry and Molecular Biology
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Human Genetics (IHG)