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Open Access Green as soon as Postprint is submitted to ZB.
Targeted inactivation of p53 in human cells does not result in aneuploidy.
Cancer Res. 62, 1129-1133 (2002)
Because p53 mutation and aneuploidy usually coexist, it has been suggested that p53 inactivation leads to aneuploidy. We have rigorously tested this hypothesis in diploid human cell lines in which p53 was experimentally inactivated by targeted homologous recombination. Cells completely deficient in p53 did not become aneuploid, although a slight tendency toward tetraploidization was observed. No increased rates of numerical or structural chromosomal instabilities were observed in the p53-deficient cells. Rates of sister chromatid exchange and homologous recombination were also unaffected by p53 status. These results show that inactivation of p53 does not, in and of itself, lead to the development of aneuploidy.
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Publication type
Article: Journal article
Document type
Scientific Article
Language
english
Publication Year
2002
HGF-reported in Year
0
ISSN (print) / ISBN
0008-5472
e-ISSN
1538-7445
Journal
Cancer Research
Quellenangaben
Volume: 62,
Issue: 4,
Pages: 1129-1133
Publisher
American Association for Cancer Research (AACR)
Publishing Place
Philadelphia, Pa.
Reviewing status
Peer reviewed
Institute(s)
Institute of Human Genetics (IHG)
PubMed ID
11861393
Erfassungsdatum
2002-12-31