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Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
Carcinogen-specific induction of genetic instability.
Proc. Natl. Acad. Sci. U.S.A. 98, 5770-5775 (2001)
It has been proposed recently that the type of genetic instability in cancer cells reflects the selection pressures exerted by specific carcinogens. We have tested this hypothesis by treating immortal, genetically stable human cells with representative carcinogens. We found that cells resistant to the bulky-adduct-forming agent 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) exhibited a chromosomal instability (CIN), whereas cells resistant to the methylating agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) exhibited a microsatellite instability (MIN) associated with mismatch repair defects. Conversely, we found that cells purposely made into CIN cells are resistant to PhIP, whereas MIN cells are resistant to MNNG. These data demonstrate that exposure to specific carcinogens can indeed select for tumor cells with distinct forms of genetic instability and vice versa.
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Publication type
Article: Journal article
Document type
Scientific Article
Language
english
Publication Year
2001
HGF-reported in Year
0
ISSN (print) / ISBN
0027-8424
e-ISSN
1091-6490
Quellenangaben
Volume: 98,
Issue: 10,
Pages: 5770-5775
Publisher
National Academy of Sciences
Reviewing status
Peer reviewed
Institute(s)
Institute of Human Genetics (IHG)
PubMed ID
11296254
Erfassungsdatum
2001-12-31