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Jallepalli, P.V.* ; Waizenegger, I.C.* ; Bunz, F.* ; Langer, S.* ; Speicher, M.R.* ; Peters, J.M.* ; Kinzler, K.W.* ; Vogelstein, B.* ; Lengauer, C.*

Securin is required for chromosomal stability in human cells.

Cell 105, 445-457 (2001)
PMC
Open Access Green as soon as Postprint is submitted to ZB.
Abnormalities of chromosome number are the most common genetic aberrations in cancer. The mechanisms regulating the fidelity of mitotic chromosome transmission in mammalian cells are therefore of great interest. Here we show that human cells without an hSecurin gene lose chromosomes at a high frequency. This loss was linked to abnormal anaphases during which cells underwent repetitive unsuccessful attempts to segregate their chromosomes. The abnormal mitoses were associated with biochemical defects in the activation of separin, the sister-separating protease, rendering it unable to cleave the cohesin subunit Scc1 efficiently. These results illuminate the function of mammalian securin and show that it is essential for the maintenance of euploidy.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2001
HGF-reported in Year 0
ISSN (print) / ISBN 0092-8674
e-ISSN 1097-4172
Journal Cell
Quellenangaben Volume: 105, Issue: 4, Pages: 445-457 Article Number: , Supplement: ,
Publisher Cell Press
Publishing Place Cambridge, Mass.
Reviewing status Peer reviewed
Institute(s) Institute of Human Genetics (IHG)
PubMed ID 11371342
Erfassungsdatum 2001-12-31
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