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Open Access Green as soon as Postprint is submitted to ZB.
Karyotyping mouse chromosomes by multiplex-FISH (M-FISH).
Chromosome Res. 9, 211-214 (2001)
Karyotyping of mouse chromosomes is a skillful art, which is laborious work even for experienced cytogeneticists. With the growing number of mouse models for human diseases, there is an increasing demand for automated mouse karyotyping systems. Here, such a karyotyping system for mouse chromosomes based on the multiplex-fluorescence in-situ hybridization (M-FISH) technology is shown. The system was tested on a number of individual mice with numerical and structural aberrations and its reproducibility and robustness verified. Mouse M-FISH should be a valuable tool for the analysis of chromosomal rearrangements in mice.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
fluorescence in situ hybridization (FISH); karyotyping; mouse chromosomes; multiplex-FISH (M-FISH); translocations; MULTICOLOR; TRANSLOCATIONS; HYBRIDIZATION; ABERRATIONS; MICE
ISSN (print) / ISBN
0967-3849
e-ISSN
1573-6849
Journal
Chromosome Research
Quellenangaben
Volume: 9,
Issue: 3,
Pages: 211-214
Publisher
Springer
Non-patent literature
Publications
Reviewing status
Peer reviewed