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Hossann, M. ; Wang, T. ; Syunyaeva, Z.* ; Wiggenhorn, M.* ; Zengerle, A.* ; Issels, R.D. ; Reiser, M.* ; Lindner, L.H. ; Peller, M.*

Non-ionic Gd-based MRI contrast agents are optimal for encapsulation into phosphatidyldiglycerol-based thermosensitive liposomes.

J. Control. Release 166, 22-29 (2013)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Thermosensitive liposomes (TSL) with encapsulated magnetic resonance imaging (MRI) longitudinal relaxation time (T-1) contrast agents (CAs) have been proposed for MRI assisted interventional thermotherapy in solid tumors. Here the feasibility of 6 clinically approved CAs (Gd-DTPA, Gd-BOPTA, Gd-DOTA, Gd-BT-DO3A, Gd-DTPA-BMA, and Gd-HP-DO3A) for formulation into TSL was investigated. CAs were passively encapsulated with 323 mOs kg(-1) into 1,2-dipalmitoyl-sn-glycero-3-phosphocholine/1,2-distearoyl-sn-glycero-3-phosphocholine/1,2-dipalmitoyl-sn-glycero-3-phosphodiglycerol 50/20/30 (mol/mol) TSL (DPPG(2)-TSL) to obtain stable formulations. T-1 relaxivity (r(1)) and diffusive permeability to water (P-d) across the membrane were determined. Shelf life at 4 degrees C was investigated by determining lysolipid content up to 10 weeks after preparation. All preparations were monodispersed with comparable small vesicle sizes (similar to 135 nm). Neither zeta potential nor phase transition temperature (T-m) was affected by the CA. The formulations showed an increase in r1 in the temperature range between 38 and 44 degrees C. This correlated with the phase transition.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Gd-based Contrast Agent ; Proton Magnetic Resonance ; Hyperthermia ; Thermosensitive Liposomes ; Phosphatidyloligoglycerol; Temperature-sensitive Liposomes ; Intensity Focused Ultrasound ; In-vitro ; Drug-delivery ; Paramagnetic Liposomes ; Physicochemical Properties ; Content Release ; Hyperthermia ; Stability ; Vesicles
ISSN (print) / ISBN 0168-3659
e-ISSN 1873-4995
Journal Journal of Controlled Release
Quellenangaben Volume: 166, Issue: 1, Pages: 22-29 Article Number: , Supplement: ,
Publisher Elsevier
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) CCG Tumor Therapy with Hyperthermia (IMI-KTH)