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Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
Equine recurrent uveitis: A spontaneous horse model of uveitis.
Ophthalmic Res. 40, 151-153 (2008)
Equine recurrent uveitis (ERU) is an autoimmune disease that occurs with a high prevalence (10%) in horses. ERU represents the only reliable spontaneous model for human autoimmune uveitis. We already identified and characterized novel autoantigens (malate dehydrogenase, recoverin, CRALBP) by analyzing the autoantibody-binding pattern of horses affected by spontaneous recurrent uveitis (ERU) to the retinal proteome. CRALBP also seems to be relevant to human autoimmune uveitis. Proteomic screening of vitreous and retinal samples from ERU diseased cases in comparison to healthy controls has led to the identification of a series of differentially regulated proteins, which are functionally linked to the immune system and the maintenance of the blood-retinal barrier
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1.250
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Uveitis; spontaneous model; horse; Autoimmune; Target organ; Autoantigens; Proteomics; Regulated proteins
Language
english
Publication Year
2008
HGF-reported in Year
2008
ISSN (print) / ISBN
0030-3747
e-ISSN
1423-0259
Journal
Ophthalmic Research
Quellenangaben
Volume: 40,
Issue: 3-4,
Pages: 151-153
Publisher
Karger
Reviewing status
Peer reviewed
Institute(s)
CF Metabolomics & Proteomics (CF-MPC)
POF-Topic(s)
30203 - Molecular Targets and Therapies
Research field(s)
Enabling and Novel Technologies
PSP Element(s)
G-505700-001
Scopus ID
42449144794
Erfassungsdatum
2008-08-29