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Schormann, W.* ; Kraft, A.* ; Ponsel, D.* ; Bruss, V.*

Hepatitis B virus particle formation in the absence of pregenomic RNA and reverse transcriptase.

J. Virol. 80, 4187-4190 (2006)

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Open Access Green as soon as Postprint is submitted to ZB.

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Cytoplasmic hepatitis B virus (HBV) capsids are not enveloped and secreted unless the packaged RNA pregenome is reverse transcribed. The expression of the capsid protein C, together with envelope proteins in the absence of pregenomic RNA, produced normal amounts of intracellular capsids, but the secretion of virion-like particles was greatly reduced. The I97L C protein mutant, allowing immature nucleocapsid envelopment in the background of an HBV genome, did not promote the envelopment of capsids lacking a pregenome, suggesting that this mutation is not sufficient to induce secretion competence independently of the pregenome.

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Publication type Article: Journal article

Document type Scientific Article

ISSN (print) / ISBN 0022-538X

e-ISSN 1098-5514

Journal Journal of Virology

Quellenangaben Volume: 80, Issue: 8, Pages: 4187-4190

Publisher American Society for Microbiology (ASM)

Reviewing status Peer reviewed

Institute(s) Institute of Virology (VIRO)