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Kluge, B.* ; Schläger, M.* ; Pairan, A.* ; Bruss, V.*

Determination of the minimal distance between the matrix and transmembrane domains of the large hepatitis B virus envelope protein.

J. Virol. 79, 7918-7921 (2005)

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Open Access Green as soon as Postprint is submitted to ZB.

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The cytosolic matrix domain (MD) located between amino acids (aa) 103 and 124 of the large hepatitis B virus envelope protein L is essential for virion formation. We reduced the distance between MD and the transmembrane domain (TD; aa 254 to 272) by deletions starting at aa 132. Six mutants with deletions of up to aa 234 were wild type, and four mutants with slightly larger deletions were blocked with respect to virion morphogenesis. Thus, the minimal distance between MD and TD was around 26 aa. This spacer might be required by MD to reach contact sites on the capsid.

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Publication type Article: Journal article

Document type Scientific Article

ISSN (print) / ISBN 0022-538X

e-ISSN 1098-5514

Journal Journal of Virology

Quellenangaben Volume: 79, Issue: 12, Pages: 7918-7921

Publisher American Society for Microbiology (ASM)

Reviewing status Peer reviewed

Institute(s) Institute of Virology (VIRO)