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Hultström, A.L.* ; Bratt, G.* ; Cosma, A. ; Erfle, V. ; Wahren, B.* ; Carbone, E.*

Autologous cytotoxicity of natural killer cells derived from HIV-infected patients.

Immunol. Lett. 91, 155-158 (2004)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
NK cells recognize target cells with reduced expression of MHC class I molecules. Human immunodeficiency virus (HIV) infection decreases MHC class I on the cell membrane. The aim of this study was to directly evaluate the role and conditions of NK cell effects in HIV seropositive patients ex vivo. Autologous HIV-infected CD4+ T cells were exposed to NK cells recognition. We discovered an increased lysis of the target cells after infection with human immunodeficiency virus-1 (HIV-1). The expression of the HIV-1 nef gene or the combined expression of nef and tat confers NK susceptibility to autologous CD4+ targets. Downregulation of MHC class I but not HLA-C or CD4 correlated with increased recognition by NK cells. The specific recognition is correlated with downregulation of MHC class I molecules on the infected target cells.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Hiv ; Mhc Class I ; Nk
Language english
Publication Year 2004
HGF-reported in Year 0
ISSN (print) / ISBN 0165-2478
e-ISSN 1879-0542
Journal Immunology Letters
Quellenangaben Volume: 91, Issue: 2-3, Pages: 155-158 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) Institute of Virology (VIRO)
PubMed ID 15019284
DOI 10.1016/j.imlet.2003.11.012
Scopus ID 1542302600
Erfassungsdatum 2004-12-31
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