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Baarsma, H.A. ; Königshoff, M. ; Gosens, R.*

The WNT signaling pathway from ligand secretion to gene transcription: Molecular mechanisms and pharmacological targets.

Pharmacol. Ther. 138, 66-83 (2013)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Wingless/integrase-1 (WNT) signaling is a key pathway regulating various aspects of embryonic development; however it also underlies several pathological conditions in man, including various cancers and fibroproliferative diseases in several organs. Investigating the molecular processes involved in (canonical) WNT signaling will open new avenues for generating new therapeutics to specifically target diseases in which WNT signaling is aberrantly regulated. Here we describe the complexity of WNT signal transduction starting from the processes involved in WNT ligand biogenesis and secretion by WNT producing cells followed by a comprehensive overview of the molecular signaling events ultimately resulting in enhanced transcription of specific genes in WNT receiving cells. Finally, the possible targets for therapeutic intervention and the available pharmacological inhibitors for this complex signaling pathway are discussed.
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Publication type Article: Journal article
Document type Review
Keywords Beta-catenin ; Frizzled (fzd) ; Lipoprotein Receptor Related Proteins (lrp) ; Axin ; Casein Kinase (ck) ; Dishevelled (dvl); Glycogen-synthase Kinase-3 ; Frizzled-related Protein-1 ; Idiopathic Pulmonary-fibrosis ; Catenin Destruction Complex ; Receptor-related Protein-5 ; Cysteine-rich Domain ; Apc Tumor-suppressor ; Human Colon-cancer ; Beta-catenin ; Nuclear-localization
Language english
Publication Year 2013
HGF-reported in Year 2013
ISSN (print) / ISBN 0163-7258
e-ISSN 1879-016X
Journal Pharmacology & Therapeutics.
Quellenangaben Volume: 138, Issue: 1, Pages: 66-83 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) German Center for Lung Research (DZL)
Institute of Lung Health and Immunity (LHI)
POF-Topic(s) 80000 - German Center for Lung Research
30503 - Chronic Diseases of the Lung and Allergies
Research field(s) Lung Research
PSP Element(s) G-501800-855
G-551800-001
PubMed ID 23328704
DOI 10.1016/j.pharmthera.2013.01.002
WOS ID WOS:000316520600006
Erfassungsdatum 2013-04-18
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