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Nößner, E. ; Brech, D. ; Mendler, A.N. ; Masouris, I. ; Schlenker, R. ; Prinz, P.U.

Intratumoral alterations of dendritic-cell differentiation and CD8+ T-cell energy are immune escape mechanisms of clear cell renal cell carcinoma.

OncoImmunology 1, 1451-1453 (2012)
DOI PMC
Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
Cytotoxic lymphocytes and dendritic cells infiltrating human renal cell carcinoma (RCC) are not sufficient to prevent tumor progression. Our studies identified alterations of the immune cell infiltrate as well as some of the underlying mechanisms. This knowledge should facilitate the development of anti-RCC therapies that achieve better tumor control.
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Publication type Article: Journal article
Document type Comment, Opinion
Keywords Dendritic Cells ; Immune Escape ; Renal Cell Carcinoma ; Tumor-infiltrating Lymphocytes ; Tumor Milieu
ISSN (print) / ISBN 2162-4011
e-ISSN 2162-402X
Journal OncoImmunology
Quellenangaben Volume: 1, Issue: 8, Pages: 1451-1453 Article Number: , Supplement: ,
Publisher Taylor & Francis
Publishing Place Philadelphia
Reviewing status Peer reviewed
Institute(s) Institute of Molecular Immunology (IMI)