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Fröhlich, M.* ; Sund, M. ; Löwel, H. ; Imhof, A.* ; Hoffmeister, A.* ; Koenig, W.*

Independent association of various smoking characteristics with markers of systemic inflammation in men. Results from a representative sample of the general population (MONICA Augsburg Survey 1994/95).

Eur. Heart J. 24, 1365-1372 (2003)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
AIMS: Aim of the study was to investigate the association between various markers of systemic inflammation and a detailed history of smoking in a large representative sample of the general population. METHODS AND RESULTS: The effects of chronic smoking on white blood cell (WBC) count, fibrinogen, albumin, plasma viscosity (PV), and high-sensitivity C-reactive protein (CRP) were measured in 2305 men and 2211 women, age 25-74 years, participating in the third MONICA Augsburg survey 1994/95. In men, current smokers showed statistically significantly higher values for WBC count, fibrinogen, PV, and CRP, compared to never smokers, with intermediate, but only slightly increased values for ex-smokers and for occasional smokers. No consistent associations were seen with albumin. Duration of smoking was positively associated with markers of inflammation as were pack-years of smoking. Conversely, duration of abstinence from smoking was inversely related to these markers. Except for WBC count, no such associations were found in women. CONCLUSION: Data from this large representative population show strong associations between smoking and various markers of systemic inflammation in men. They also show that cessation of smoking is associated with a decreased inflammatory response, which may represent one mechanism responsible for the reduced cardiovascular risk in these subjects.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords smoking; inflammation; C-reactive protein; fibrinogen; plasma viscosity; white blood cell count; C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; CARDIOVASCULAR RISK-FACTORS; BLOOD-CELL COUNT; ACUTE-PHASE PROTEINS; CIGARETTE-SMOKING; PLASMA-VISCOSITY; MYOCARDIAL-INFARCTION; ARTERY DISEASE; ATHEROSCLEROSIS
ISSN (print) / ISBN 0195-668X
e-ISSN 1522-9645
Journal European Heart Journal
Quellenangaben Volume: 24, Issue: 14, Pages: 1365-1372 Article Number: , Supplement: ,
Publisher Oxford University Press
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Health Economics and Health Care Management (IGM)
Institute of Epidemiology (EPI)