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Zareba, W.* ; Couderc, J.P.* ; Oberdörster, G.* ; Chalupa, D.* ; Cox, C.* ; Huang, L.-S.* ; Peters, A. ; Utell, M.J.* ; Frampton, M.W.*

ECG parameters and exposure to carbon ultrafine particles in young healthy subjects.

Inhal. Toxicol. 21, 223-233 (2009)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
The mechanisms underlying the association between air pollution and cardiovascular morbidity and mortality are unknown. This study aimed to determine whether controlled exposure to elemental carbon ultrafine particles (UFP) affects electrocardiogram (ECG) parameters describing heart rate variability; repolarization duration, morphology, and variability; and changes in the ST segment. Two separate controlled studies (12 subjects each) were performed using a crossover design, in which each subject was exposed to filtered air and carbon UFP for 2 hours. The first protocol involved 2 exposures to air and 10 g/m3 ( 2 106 particles/cm3, count median diameter 25 nm, geometric standard deviation 1.6), at rest. The second protocol included 3 exposures to air, 10, and 25 g/m3 UFP ( 7 106 particles/cm3), with repeated exercise. Each subject underwent a continuous digital 12-lead ECG Holter recording to analyze the above ECG parameters. Repeated measures analysis of variance (ANOVA) was used to compare tested parameters between exposures. The observed responses to UFP exposure were small and generally not significant, although there were trends indicating an increase in parasympathetic tone, which is most likely also responsible for trends toward ST elevation, blunted QTc shortening, and increased variability of T-wave complexity after exposure to UFP. Recovery from exercise showed a blunted response of the parasympathetic system after exposure to UFP in comparison to air exposure. In conclusion, transient exposure to 10-25 g/m3 ultrafine carbon particles does not cause marked changes in ECG-derived parameters in young healthy subjects. However, trends are observed indicating that some subjects might be susceptible to air pollution, with a response involving autonomic modulation of the heart and repolarization of the ventricular myocardium.
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Publication type Article: Journal article
Document type Scientific Article
Keywords heart-rate-variability; particulate air-pollution; myocardial-infarction; autonomic dysfunction; asthmatic volunteers; los-angeles; disease; inflammation; mechanisms; inhalation
Language english
Publication Year 2009
HGF-reported in Year 2009
ISSN (print) / ISBN 0895-8378
e-ISSN 1091-7691
Journal Inhalation Toxicology
Quellenangaben Volume: 21, Issue: 3, Pages: 223-233 Article Number: , Supplement: ,
Publisher Informa Healthcare
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
PSP Element(s) G-503900-005
G-503900-004
PubMed ID 18991063
DOI 10.1080/08958370802492407
Scopus ID 60749133801
Erfassungsdatum 2009-07-09
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