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Disparate individual fates compose robust CD8+ T cell immunity.
Science 340, 630-635 (2013)
Publ. Version/Full Text Volltext
DOI
PMC
A core feature of protective T cell responses to infection is the robust expansion and diversification of naïve antigen-specific T cell populations into short-lived effector and long-lived memory subsets. By in vivo fate mapping, we find a striking variability of immune responses derived from individual CD8+ T cells and show that robust acute and recall immunity requires the initial recruitment of multiple precursors. Unbiased mathematical modeling identifies the random integration of multiple differentiation and division events as the driving force behind this variability. Within this probabilistic framework, cell fate is specified along a linear developmental path that progresses from slowly proliferating long-lived to rapidly expanding short-lived subsets. These data provide insights into how complex biological systems implement stochastic processes to guarantee robust outcomes.
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31.027
8.060
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Transcription Factor ; Cutting Edge ; Memory ; Effector ; Precursor ; Subsets ; Stem ; Differentiation ; Expansion ; Division
Language
english
Publication Year
2013
HGF-reported in Year
2013
ISSN (print) / ISBN
0036-8075
e-ISSN
1095-9203
Journal
Science
Quellenangaben
Volume: 340,
Issue: 6132,
Pages: 630-635
Publisher
American Association for the Advancement of Science (AAAS)
Reviewing status
Peer reviewed
POF-Topic(s)
30203 - Molecular Targets and Therapies
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s)
Immune Response and Infection
PSP Element(s)
G-502700-001
G-502700-003
G-501790-002
G-520100-001
G-501790-003
G-502700-003
G-501790-002
G-520100-001
G-501790-003
WOS ID
WOS:000318268900053
PubMed ID
23493420
Erfassungsdatum
2013-04-22