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Buchholz, V.R.* ; Flossdorf, M.* ; Hensel, I.* ; Kretschmer, L.* ; Weißbrich, B.* ; Gräf, P.* ; Verschoor, A.* ; Schiemann, M. ; Höfer, T.* ; Busch, D.H.

Disparate individual fates compose robust CD8+ T cell immunity.

Science 340, 630-635 (2013)
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A core feature of protective T cell responses to infection is the robust expansion and diversification of naïve antigen-specific T cell populations into short-lived effector and long-lived memory subsets. By in vivo fate mapping, we find a striking variability of immune responses derived from individual CD8+ T cells and show that robust acute and recall immunity requires the initial recruitment of multiple precursors. Unbiased mathematical modeling identifies the random integration of multiple differentiation and division events as the driving force behind this variability. Within this probabilistic framework, cell fate is specified along a linear developmental path that progresses from slowly proliferating long-lived to rapidly expanding short-lived subsets. These data provide insights into how complex biological systems implement stochastic processes to guarantee robust outcomes.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Transcription Factor ; Cutting Edge ; Memory ; Effector ; Precursor ; Subsets ; Stem ; Differentiation ; Expansion ; Division
ISSN (print) / ISBN 0036-8075
e-ISSN 1095-9203
Journal Science
Quellenangaben Volume: 340, Issue: 6132, Pages: 630-635 Article Number: , Supplement: ,
Publisher American Association for the Advancement of Science (AAAS)
Reviewing status Peer reviewed
Institute(s) Institute of Virology (VIRO)
Institute of Molecular Immunology (IMI)