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Open Access Green as soon as Postprint is submitted to ZB.
Identification of differentially expressed proteins in triple-negative breast carcinomas using DIGE and mass spectrometry.
J. Proteome Res. 8, 3430-3438 (2009)
We compared the protein expression pattern of triple-negative breast carcinomas (HER2-, ER-, PR-) versus those being positive for HER2 and negative for the hormone receptors (HER2+, ER-, PR-) by 2-D DIGE and mass spectrometry. We obtained differential expression patterns for several glycolytic enzymes (as for example MDH2, PGK1, TKT, Aldolase1), cytokeratins (CK7, 8, 9, 14, 17, 19), further structure proteins (vimentin, fibronectin, L-plastin), for NME1-NME2, lactoferrin, and members of the Annexin family. Western blot analysis and immunohistochemistry were conducted to verify the results. The identified marker proteins may advance a more detailed characterization of triple-negative breast cancers and may contribute to the development of better treatment strategies.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
proteomics; breast cancer; triple-negative; 2D-DIGE; MALDI-TOF/TOFMS; annexin a1 expression; nf-kappa-b; oxidative stress; epithelial-cells; messenger-rna; cancer cells; lactoferrin; tumors; progression; receptor
Language
english
Publication Year
2009
HGF-reported in Year
2009
ISSN (print) / ISBN
1535-3893
e-ISSN
1535-3907
Journal
Journal of Proteome Research
Quellenangaben
Volume: 8,
Issue: 7,
Pages: 3430-3438
Publisher
American Chemical Society (ACS)
Reviewing status
Peer reviewed
POF-Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30202 - Environmental Health
30202 - Environmental Health
Research field(s)
Enabling and Novel Technologies
Radiation Sciences
Radiation Sciences
PSP Element(s)
G-500300-001
G-500200-001
G-500200-001
PubMed ID
19485423
Scopus ID
67650388533
Erfassungsdatum
2009-09-03