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The Negatome database: A reference set of non-interacting protein pairs.
Nucleic Acids Res. 38, 1, D540-D544 (2010)
The Negatome is a collection of protein and domain pairs that are unlikely to be engaged in direct physical interactions. The database currently contains experimentally supported non-interacting protein pairs derived from two distinct sources: by manual curation of literature and by analyzing protein complexes with known 3D structure. More stringent lists of non-interacting pairs were derived from these two datasets by excluding interactions detected by high-throughput approaches. Additionally, non-interacting protein domains have been derived from the stringent manual and structural data, respectively. The Negatome is much less biased toward functionally dissimilar proteins than the negative data derived by randomly selecting proteins from different cellular locations. It can be used to evaluate protein and domain interactions from new experiments and improve the training of interaction prediction algorithms. The Negatome database is available at http://mips.helmholtz-muenchen.de/proj/ppi/negatome.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
PREDICTION; RESOURCE; DOMAIN; COMPLEXES; SEQUENCES; STANDARD; SCALE
ISSN (print) / ISBN
0305-1048
e-ISSN
1362-4962
Journal
Nucleic Acids Research
Quellenangaben
Volume: 38,
Issue: Database Issue,
Pages: D540-D544,
Supplement: 1
Publisher
Oxford University Press
Non-patent literature
Publications
Reviewing status
Peer reviewed