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Open Access Green as soon as Postprint is submitted to ZB.
Trnp1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate.
Cell 153, 535-549 (2013)
Evolution of the mammalian brain encompassed a remarkable increase in size of the cerebral cortex, which includes tangential and radial expansion. However, the mechanisms underlying these key features are still largely unknown. Here, we identified the DNA-associated protein Trnp1 as a regulator of cerebral cortex expansion in both of these dimensions. Gain- and loss-of-function experiments in the mouse cerebral cortex in vivo demonstrate that high Trnp1 levels promote neural stem cell self-renewal and tangential expansion. In contrast, lower levels promote radial expansion, with a potent increase of the number of intermediate progenitors and basal radial glial cells leading to folding of the otherwise smooth murine cerebral cortex. Remarkably, TRNP1 expression levels exhibit regional differences in the cerebral cortex of human fetuses, anticipating radial or tangential expansion. Thus, the dynamic regulation of Trnp1 is critical to control tangential and radial expansion of the cerebral cortex in mammals.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Developing Mouse Neocortex ; Outer Subventricular Zone ; Lissencephalic Primate ; Embryonic Neocortex ; Progenitor-cell ; Germinal Zones ; Evolution ; Neurogenesis ; Expression ; Differentiation
ISSN (print) / ISBN
0092-8674
e-ISSN
1097-4172
Journal
Cell
Quellenangaben
Volume: 153,
Issue: 3,
Pages: 535-549
Publisher
Cell Press
Publishing Place
Cambridge, Mass.
Non-patent literature
Publications
Reviewing status
Peer reviewed