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Kutschke, M. ; Grimpo, K.* ; Kastl, A.* ; Schneider, S.* ; Heldmaier, G.* ; Exner, C.* ; Jastroch, M.

Depression of mitochondrial respiration during daily torpor of the Djungarian hamster, Phodopus sungorus, is specific for liver and correlates with body temperature.

Comp. Biochem. Physiol. A-Mol. Integr. Physiol. 164, 584-589 (2013)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Small mammals actively decrease metabolism during daily torpor and hibernation to save energy. Increasing evidence suggests depression of mitochondrial respiration during daily torpor of the Djungarian hamster but tissue-specificity and relation to torpor depth is unknown. We first confirmed a previous study by Brown and colleagues reporting on the depressed substrate oxidation in isolated liver mitochondria of the Djungarian hamster (Phodopus sungorus) during daily torpor. Next, we show that mitochondrial respiration is not depressed in kidneys, skeletal muscle and heart. In liver mitochondria, we found that state 3 and state 4 respirations correlate with body temperature, suggesting inhibition related to torpor depth and to metabolic rate. We conclude that molecular events leading to depression of mitochondrial respiration during daily torpor are specific to liver and linked to a decrease in body temperature. Different tissue-specificity of mitochondrial depression may assist to compare and identify the molecular nature of mitochondrial alterations during torpor.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Mitochondrial Respiration ; Daily Torpor ; Hypothermia ; Hypometabolism ; Phodopus Sungorus; Metabolic-rate ; Proton Leak ; Reversible Depression ; Hibernation ; Mammals ; Suppression ; Transcription ; Inhibition ; Animals ; Birds
ISSN (print) / ISBN 1095-6433
e-ISSN 1095-6433
Journal Comparative Biochemistry and Physiology. Part A: Molecular & Integrative Physiology
Quellenangaben Volume: 164, Issue: 4, Pages: 584-589 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)