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Potential of the trifunctional bispecific antibody Surek depends on dendritic cells: Rationale for a new approach of tumor immunotherapy.
Mol. Med. 19, 54-61 (2013)
Trifunctional bispecific antibodies (trAbs) used in tumor immunotherapy have the unique ability to recruit T cells toward antigens on the tumor cell surface and, moreover, to activate accessory cells through their immunoglobulin Fc region interacting with activating Fcγ receptors. This scenario gives rise to additional costimulatory signals required for T cell–mediated tumor cell destruction and induction of an immunologic memory. Here we show in an in vitro system that most effective trAb-dependent T-cell activation and tumor cell elimination are achieved in the presence of dendritic cells (DCs). On the basis of these findings, we devise a novel approach of cancer immunotherapy that combines the specific advantages of trAbs with those of DC-based vaccination. Simultaneous delivery of trAbs and in vitro differentiated DCs resulted in a markedly improved tumor rejection in a murine melanoma model compared with monotherapy.
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4.469
1.294
6
8
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
T-cells ; In-vivo ; Cancer-immunotherapy ; Monoclonal-antibody ; Malignant Ascites ; Accessory Cells ; Lymphoma-cells ; Immunity ; Therapy ; Vaccination
Language
english
Publication Year
2013
HGF-reported in Year
2013
ISSN (print) / ISBN
1076-1551
e-ISSN
1435-8123
Journal
Molecular Medicine
Quellenangaben
Volume: 19,
Issue: 1,
Pages: 54-61
Publisher
Feinstein Inst. for Medical Research
Reviewing status
Peer reviewed
Institute(s)
Institute of Molecular Immunology (IMI)
POF-Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s)
Immune Response and Infection
PSP Element(s)
G-501700-006
G-501793-001
G-501793-001
PubMed ID
23552725
WOS ID
WOS:000328604200006
Scopus ID
84877098589
Erfassungsdatum
2013-05-07