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Schendel, D.J. ; Frankenberger, B.

Limitations for TCR gene therapy by MHC-restricted fratricide and TCR-mediated hematopoietic stem cell toxicity.

OncoImmunology 2:e22410 (2013)

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Open Access Green as soon as Postprint is submitted to ZB.

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The clinical use of lymphocytes engineered to express high affinity T-cell receptors (TCRs) specific for two broadly expressed tumor-associated antigens is strongly limited by MHC-restricted fratricide of lymphocytes and TCR-mediated killing of hematopoietic stem cells. Specific clinical applications must therefore be conceived to bypass these limitations.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Hematopoietic Stem Cell Toxicity ; Hyluronan-mediated Motility Receptor ; Mhc-restricted Fratricide ; Survivin ; Tcr Gene Therapy; T-cells ; Dendritic Cells ; Antigens

ISSN (print) / ISBN 2162-4011

e-ISSN 2162-402X

Journal OncoImmunology

Quellenangaben Volume: 2, Issue: 1, Article Number: e22410

Publisher Taylor & Francis

Publishing Place Philadelphia

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Molecular Immunology (IMI)