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Limitations for TCR gene therapy by MHC-restricted fratricide and TCR-mediated hematopoietic stem cell toxicity.

OncoImmunology 2:e22410 (2013)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
The clinical use of lymphocytes engineered to express high affinity T-cell receptors (TCRs) specific for two broadly expressed tumor-associated antigens is strongly limited by MHC-restricted fratricide of lymphocytes and TCR-mediated killing of hematopoietic stem cells. Specific clinical applications must therefore be conceived to bypass these limitations.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Hematopoietic Stem Cell Toxicity ; Hyluronan-mediated Motility Receptor ; Mhc-restricted Fratricide ; Survivin ; Tcr Gene Therapy; T-cells ; Dendritic Cells ; Antigens
ISSN (print) / ISBN 2162-4011
e-ISSN 2162-402X
Journal OncoImmunology
Quellenangaben Volume: 2, Issue: 1, Pages: , Article Number: e22410 Supplement: ,
Publisher Taylor & Francis
Publishing Place Philadelphia
Non-patent literature Publications
Reviewing status Peer reviewed