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Limitations for TCR gene therapy by MHC-restricted fratricide and TCR-mediated hematopoietic stem cell toxicity.
OncoImmunology 2:e22410 (2013)
The clinical use of lymphocytes engineered to express high affinity T-cell receptors (TCRs) specific for two broadly expressed tumor-associated antigens is strongly limited by MHC-restricted fratricide of lymphocytes and TCR-mediated killing of hematopoietic stem cells. Specific clinical applications must therefore be conceived to bypass these limitations.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Hematopoietic Stem Cell Toxicity ; Hyluronan-mediated Motility Receptor ; Mhc-restricted Fratricide ; Survivin ; Tcr Gene Therapy; T-cells ; Dendritic Cells ; Antigens
ISSN (print) / ISBN
2162-4011
e-ISSN
2162-402X
Journal
OncoImmunology
Quellenangaben
Volume: 2,
Issue: 1,
Article Number: e22410
Publisher
Taylor & Francis
Publishing Place
Philadelphia
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Molecular Immunology (IMI)