PuSH - Publication Server of Helmholtz Zentrum München: Reduced suppressive effect of (CD4plus)CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis.

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... Journal

... Publication Type

... Research Data

... Publication Year

Publication overview

Support & Contact

Contact persons

Help

Data protection

Haas, J.* ; Hug, A.* ; Viehöver, A.* ; Fritzsching, B.* ; Falk, C.S. ; Filser, A.* ; Vetter, T.* ; Milkova, L.* ; Korporal, M.* ; Fritz, B.* ; Storch-Hagenlocher, B.*

Reduced suppressive effect of (CD4plus)CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis.

Eur. J. Immunol. 35, 3343-3352 (2005)

DOI

Open Access Green as soon as Postprint is submitted to ZB.

Abstract
Metrics
Extra information

Immunoregulatory T cells of CD4⁺CD25⁺ phenotype suppress T cell function and protect rodents from organ-specific autoimmune disease. The human counterpart of this subset of T cells expresses high levels of CD25 and its role in human autoimmune disorders is currently under intense investigation. In multiple sclerosis (MS), a chronic inflammatory disease of the central nervous system (CNS), the activation of circulating self-reactive T cells with specificity for myelin components is considered to be an important disease initiating event. Here, we investigated whether MS is associated with an altered ability of CD4⁺CD25^high regulatory T cells (T_reg) to confer suppression of myelin-specific immune responses. Whereas T_reg frequencies were equally distributed in blood and cerebrospinal fluid of MS patients and did not differ compared to healthy controls, the suppressive potency of patient-derived CD4⁺CD25^high T lymphocytes was impaired. Their inhibitory effect on antigen-specific T cell proliferation induced by human recombinant myelin oligodendrocyte protein as well as on immune responses elicited by polyclonal and allogeneic stimuli was significantly reduced compared to healthy individuals. The effect was persistent and not due to responder cell resistance or altered survival of T_reg, suggesting that a defective immunoregulation of peripheral T cells mediated by CD4⁺CD25^high T lymphocytes promotes CNS autoimmunity in MS.

Altmetric

Additional Metrics?

[➜Log in]

Edit extra informations Login

Publication type Article: Journal article

Document type Scientific Article

ISSN (print) / ISBN 0014-2980

e-ISSN 1521-4141

Journal European Journal of Immunology

Quellenangaben Volume: 35, Issue: 11, Pages: 3343-3352

Publisher Wiley

Publishing Place Hoboken

Reviewing status Peer reviewed

Institute(s) Institute of Molecular Immunology (IMI)