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Kohlboeck, G. ; Koletzko, S.* ; Bauer, C.P.* ; von Berg, A.* ; Berdel, D.* ; Krämer, U.* ; Schaaf, B.* ; Lehmann, I.* ; Herbarth, O.* ; Heinrich, J.

Association of atopic and non-atopic asthma with emotional symptoms in school children.

Pediatr. Allergy Immunol. 24, 230-236 (2013)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
OBJECTIVE: To date, there is conflicting evidence whether the association between asthma and depression depends on the atopic or non-atopic asthma phenotype. This study investigates associations between emotional symptoms and atopic and non-atopic asthma in school-aged children. METHODS: Cross-sectional data on asthma and allergic diseases at the 10-year follow-up of two birth cohorts were collected by parent-reported physician diagnoses. Specific IgE levels including most common inhalant allergens (SX1) and food allergens (FX5) were measured by RAST-CAP FEIA. Atopic asthma was defined as asthma ever and positive specific IgE test, non-atopic asthma as asthma ever and no IgE sensitization. Emotional symptoms were assessed by parent-reported strength and difficulty questionnaire. Logistic regression modeling were applied to determine likelihood of emotional symptoms in children with atopic and non-atopic asthma controlling for socio-demographic factors, body mass index, atopic eczema, allergic rhinitis, and pubertal development. RESULTS: Non-atopic asthma was associated with about 3-fold higher likelihood of emotional symptoms compared to children with no asthma (ORadj = 2.90, CI95% = 1.46-5.73). Atopic asthma was not associated with emotional symptoms (ORadj = 1.35, CI95% = 0.81-2.26). CONCLUSIONS: Atopic and non-atopic asthma in children might have different etiologies, whereas for non-atopic asthma, emotional symptoms are relevant, this is not the case in atopic asthma. The relationship between the non-atopic asthma phenotype and emotional symptoms might be dependent on gender.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Asthma ; Atopy ; Allergy ; Behavior Problems ; Epidemiology ; Depression ; Comorbidity ; Affective Disorders; Birth Cohort ; Difficulties Questionnaire ; Depression ; Disorders ; Anxiety ; Childhood ; Adolescence ; Strengths ; Gender ; Health
Language english
Publication Year 2013
HGF-reported in Year 2013
ISSN (print) / ISBN 0905-6157
e-ISSN 1399-3038
Journal Pediatric Allergy and Immunology
Quellenangaben Volume: 24, Issue: 3, Pages: 230-236 Article Number: , Supplement: ,
Publisher Wiley
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
POF-Topic(s) 30503 - Chronic Diseases of the Lung and Allergies
Research field(s) Genetics and Epidemiology
PSP Element(s) G-503900-001
PubMed ID 23590416
DOI 10.1111/pai.12056
WOS ID WOS:000317978500004
Scopus ID 84876440797
Erfassungsdatum 2013-05-15
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