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Cobreros-Reguera, L.* ; Fernández-Miñán, A.* ; Fernández-Espartero, C.H.* ; López-Schier, H.* ; González-Reyes, A.* ; Martín-Bermudo, M.D.*

The Ste20 kinase misshapen is essential for the invasive behaviour of ovarian epithelial cells in Drosophila.

EMBO Rep. 11, 943-949 (2010)
DOI PMC
Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
Stationary-to-migratory transitions of epithelial cells have a key role in development and tumour progression. Border cell migration is a powerful system in which to investigate this transition in living organisms. Here, we identify the Ste20-like kinase misshapen (msn) as a novel regulator of border-cell migration in Drosophila. Expression of msn in border cells is independent of the transcription factor slow border cells and of inputs from all pathways that are known to control border-cell migration. The msn gene functions to modulate the levels and/or distribution of Drosophila E-cadherin to promote the invasive migratory behaviour of border cells.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2010
HGF-reported in Year 0
ISSN (print) / ISBN 1469-221X
e-ISSN 1469-3178
Journal EMBO Reports
Quellenangaben Volume: 11, Issue: 12, Pages: 943-949 Article Number: , Supplement: ,
Publisher EMBO Press
Reviewing status Peer reviewed
POF-Topic(s) 30204 - Cell Programming and Repair
Research field(s) Stem Cell and Neuroscience
PSP Element(s) G-500100-001
PubMed ID 21102643
Erfassungsdatum 2010-12-31