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Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
A two-step mechanism underlies the planar polarization of regenerating sensory hair cells.
Proc. Natl. Acad. Sci. U.S.A. 103, 18615-18620 (2006)
The restoration of planar cell polarity is an essential but poorly understood step toward physiological recovery during sensory-organ regeneration. Investigating this issue in the lateral line of the zebrafish, we found that hair cells regenerate in pairs along a single axis established by the restricted localization and oriented division of their progenitors. By analyzing mutants lacking the planar-polarity determinant Vangl2, we ascertained that the uniaxial production of hair cells and the subsequent orientation of their hair bundles are controlled by distinct pathways, whose combination underlies the establishment of hair-cell orientation during development and regeneration. This mechanism may represent a general principle governing the long-term maintenance of planar cell polarity in remodeling epithelia.
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Publication type
Article: Journal article
Document type
Scientific Article
Language
english
Publication Year
2006
HGF-reported in Year
0
ISSN (print) / ISBN
0027-8424
e-ISSN
1091-6490
Quellenangaben
Volume: 103,
Issue: 49,
Pages: 18615-18620
Publisher
National Academy of Sciences
Reviewing status
Peer reviewed
POF-Topic(s)
30204 - Cell Programming and Repair
Research field(s)
Stem Cell and Neuroscience
PSP Element(s)
G-500100-001
PubMed ID
17124170
Erfassungsdatum
2006-12-31